New coumarin derivatives as carbonic anhydrase inhibitors


KARATAŞ M. O., ALICI B., Çakir Ü., Çetinkaya E., DEMİR D., Ergün A., ...More

Artificial Cells, Nanomedicine and Biotechnology, vol.42, no.3, pp.192-198, 2014 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 42 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.3109/21691401.2013.794352
  • Journal Name: Artificial Cells, Nanomedicine and Biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.192-198
  • Keywords: Benzimidazolium, Carbonic anhydrase, Coumarin, Imidazolium, Inhibition
  • Isparta University of Applied Sciences Affiliated: No

Abstract

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 μM for hCA I and 88 μM for hCA II) performed higher inhibitory activity than others. © 2014 Informa Healthcare USA, Inc.