New coumarin derivatives as carbonic anhydrase inhibitors
Artificial Cells, Nanomedicine and Biotechnology, cilt.42, sa.3, ss.192-198, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 3
- Basım Tarihi: 2014
- Doi Numarası: 10.3109/21691401.2013.794352
- Dergi Adı: Artificial Cells, Nanomedicine and Biotechnology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.192-198
- Anahtar Kelimeler: Benzimidazolium, Carbonic anhydrase, Coumarin, Imidazolium, Inhibition
- Isparta Uygulamalı Bilimler Üniversitesi Adresli: Hayır
Özet
In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 μM for hCA I and 88 μM for hCA II) performed higher inhibitory activity than others. © 2014 Informa Healthcare USA, Inc.