Research Information System
Microchemical Journal, vol.219, 2025 (SCI-Expanded, Scopus)
In the study, pencil graphite (PGE), glassy carbon (GCE) and platinum working (PtE) electrodes were prepared with two different methods (NT1 and NT2) for the electrochemical determination of cloxacillin (CLX) with a scan rate of 100 mV/s and a cycle number of 8 by cyclic voltammetry (CV) method. In order to improve the performance of the prepared nanowire electrodes, overoxidation was performed before analysis. The electrochemical behaviors of CLX on prepared nanowire-structured electrodes were investigated in phosphate buffer at pH 5.0 by differential pulse voltammetry (DPV) method. In order to increase the performance of the prepared nanowire electrodes, an overoxidation process was performed first. After the overoxidation process, the AY code was added to the electrode name codes. The linear working range was between 0.05 and 0.5 mM concentration. LOD values were determined as 0.0088 mM, 0.0141 mM, 0.0118 mM, 0.0126 mM, 0.0165 mM, and 0.0118 mM for NT1/AY/PGE, NT2/AY/PGE, NT1/AY/GCE, NT2/AY/GCE, NT1/AY/PtE, NT2/AY/PtE, respectively. It was concluded that the developed nanowire-structured electrodes showed high selectivity and sensitivity against CLX active drug substance in the presence of electroactive species that may interfere. Also, CLX active drug substance analysis was performed in a urine sample with the developed nanowire electrodes. The results showed that the nanowire-structured electrodes and the method showed high accuracy and precision in real samples. Thanks to these detection sensors being developed in the health field, important steps will be taken in personalized medical applications, such as instant monitoring of treatment processes, reduction of side effects, dose optimization, and reduction of drug costs.