Akademik Veri Yönetim Sistemi
ChemistrySelect, cilt.5, sa.25, ss.7671-7674, 2020 (SCI-Expanded, Scopus)
A copper-containing enzyme polyphenol oxidase (other name is tyrosinase) plays crucial role in melanin biosynthesis, as a compound responsible for human pigmentation. Non controlled loss of melanin can cause hypopigmentation disease. The hypopigmentatory disorder can be treated with melanogenesis stimulators. Here, twenty-four new β-lactam compounds were synthesized, characterized and in vitro effects of them on banana tyrosinase investigated. The enzyme has been purified from banana by an affinity gel comprised of Sepharose4B−L-tyrosine-p-aminobenzoic acid. The results showed that the compounds have an effect on increasing the activity of tyrosinase enzyme. Molecules having a notable tyrosinase activator effects are compound 3 h (79.86) and compound 4 n (61.30). The maximal activation, 131% was determined at 130 μM concentration. These results suggested that compounds 3 h and 4 n might represent a novel approach for an effective therapy for diseases associate with tyrosinase dysfunction, such as vitiligo and hair graying.