Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, vol.28, no.2, pp.299-304, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 28 Issue: 2
- Publication Date: 2013
- Doi Number: 10.3109/14756366.2012.677838
- Journal Name: Journal of Enzyme Inhibition and Medicinal Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.299-304
- Keywords: Benzimidazolium, Carbonic anhydrase, Coumarin, Inhibition
- Isparta University of Applied Sciences Affiliated: No
Abstract
A newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II from human erythrocytes were purified by a simple one step procedure by using Sepharose 4B-L-tyrosine-sulphanilamide affinity column. The result showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Among them, 3g and 3j were found to be most active (IC50 = 22.09 μM and 20.33 μM) for hCA I and hCA II, respectively.