Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

Sonmez F., Sevmezler S., Atahan A., Ceylan M., DEMİR D., Gencer N., ...Daha Fazla

Bioorganic and Medicinal Chemistry Letters, cilt.21, sa.24, ss.7479-7482, 2011 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 24
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.bmcl.2011.09.130
  • Dergi Adı: Bioorganic and Medicinal Chemistry Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7479-7482
  • Anahtar Kelimeler: Chalcones, Tyrosinase inhibitors
  • Isparta Uygulamalı Bilimler Üniversitesi Adresli: Evet

Özet

A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. © 2011 Elsevier Ltd. All rights reserved.