Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Bioorganic and Medicinal Chemistry Letters, cilt.21, sa.24, ss.7479-7482, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 24
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/j.bmcl.2011.09.130
- Dergi Adı: Bioorganic and Medicinal Chemistry Letters
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.7479-7482
- Anahtar Kelimeler: Chalcones, Tyrosinase inhibitors
- Isparta Uygulamalı Bilimler Üniversitesi Adresli: Evet
Özet
A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. © 2011 Elsevier Ltd. All rights reserved.