Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

Sonmez F., Sevmezler S., Atahan A., Ceylan M., DEMİR D., Gencer N., ...More

Bioorganic and Medicinal Chemistry Letters, vol.21, no.24, pp.7479-7482, 2011 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 24
  • Publication Date: 2011
  • Doi Number: 10.1016/j.bmcl.2011.09.130
  • Journal Name: Bioorganic and Medicinal Chemistry Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.7479-7482
  • Keywords: Chalcones, Tyrosinase inhibitors
  • Isparta University of Applied Sciences Affiliated: Yes

Abstract

A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. © 2011 Elsevier Ltd. All rights reserved.